Features of local and systemic production of pro-inflammatory, chemoattractant mediators and vascular growth factors in high-risk corneal transplants.

Purpose: to study the composition and content of proinflammatory cytokines, chemoattractant mediators, vascular growth factors in blood serum (SB) lacrimal fluid (LF) patients with KPHR. Materials methods. A total 106 postinflammatory corneal spots turbid transplant were examined. The control group consisted 20 practically healthy donors. Cytokines: IL-2, IL-18, MCP-1 / CCL2, MIP-1β CCL4, RANTES CCL5, Eotaxin CCL11, IP-10 CXCL10, SDF-1α CXCL12, VEGF-A, VEGF-D, PIGF-1, HGF SF. Results. levels systemic production immunomodiators groups revealed significant changes concentrations as well angiogenic VEGF-A SF compared controls. In primary KPHR presence vascularization, an increase CCL11 was observed. 1 PIGF-1 (p<0.05). Graft vascularization repeated (2 higher) transplants (group II) associated increases SC HGF/SF Analysis cytokine LF vascularized graft showed a statistically VEGF-A. retrospective analysis cytokines SB, depending on outcomes keratoplasty, concentration 7 out 11 studied various complications postoperative period, including those developed rejection reaction. Conclusions. It has been shown that formation is chemokines activity CCL5 During SB LF, unidirectional factor development initially high MIP1β PLGF, (p<0.05), indicating about activation pathological angiogenesis against background inflammation activated adaptive immune response.